DegronMD

Uniprot ID: Q8WY91

Source protein: Peroxynitrite isomerase THAP4

Source gene: THAP4

Class: LIG_APCC_ABBAyCdc20_2

Location: 476:482

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.755

ASA_SCORE: 76.0714

COIL: 0.3693

CONS_SCORE: 0.62

DSS_SCORE: 0.3886

HELIX: 0.1597

FCONS_SCORE: 1.1677

RIG_SCORE: 0.7452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R481T	TCGA-CN-6994	HNSC	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.6765
p.P490L	TCGA-EE-A29M	SKCM	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P490L	DO37404	SKCM	ICGC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T475M	TCGA-RC-A6M4	LIHC	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P490T	DO229022	LICA	ICGC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T475A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WY91	Peroxynitrite isomerase THAP4	LIG_APCC_ABBAyCdc20_2	476:482	RKPMHRE	APC,CDC20,FZR1	0.755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons