DegronMD - Q9NQU5(PAK6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R72L	TCGA-28-5211	GBM	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.2222
p.R72L	DO11016	GBM	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.2222
p.S57L	TCGA-A5-A0G2	UCEC	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.25
p.S57L	TCGA-VQ-A91K	STAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.25
p.S57L	DO51785	STAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.25
p.S57L	DO41235	UCEC	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.25
p.A75T	TCGA-AA-A01P	COAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.A75T	DO8642	COAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.R334H	TCGA-AA-A01P	COAD	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	TCGA-IB-7651	PAAD	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	DO8642	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	DO46657	PAAD	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	SIDM01040	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	ACH-000574	Ovarian Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	ACH-001737	Leukemia	CCLE	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334H	FU-OV-1	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.L333P	TCGA-AP-A1DK	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.L333P	DO42033	UCEC	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.R72W	TCGA-BR-6452	STAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.2222
p.R72W	DO38404	STAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.2222
p.S324L	TCGA-BR-8680	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7667
p.S324L	DO47769	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7667
p.P329L	TCGA-CJ-4636	KIRC	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.P329L	DO19298	KIRC	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.P52L	TCGA-DA-A1I5	SKCM	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.P52L	DO37447	SKCM	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.L333F	TCGA-DU-6407	LGG	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.L333F	DO22295	LGG	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0833
p.V53M	TCGA-F7-A624	HNSC	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.V53M	DO44440	HNSC	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.V53M	SIDM01726	Ewing's Sarcoma	GDSC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.P320S	TCGA-FW-A3R5	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6752
p.P320S	DO37406	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.6752
p.A75V	DO222955	BTCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.M76V	DO229010	COCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.M76V	DO229016	COCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.M76V	DO234285	ESAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.M76V	DO228941	LICA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1111
p.P314L	DO222671	ESCA	ICGC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.V53L	DO228978	LICA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.1389
p.P77L	SIDM00492	Glioblastoma	GDSC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.0833
p.P77L	ACH-000269	Brain Cancer	CCLE	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.0833
p.P77L	AM-38	central nervous system	COSMIC	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation rewiring degron network	0.0833
p.R334C	SIDM00014	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334C	SIDM00383	Gastric Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.R334C	SIDM01111	Ewing's Sarcoma	GDSC	PLTTS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.0556
p.S277N	SIDM01051	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7069
p.S277N	ACH-000936	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7069
p.S277N	EFO-27	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7069
p.P274A	SIDM00006	Other Solid Cancers	GDSC	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.6392
p.P274A	ACH-001552	Skin Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.6392
p.P274A	MCC26	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.6392
p.V62M	ACH-000943	Colon/Colorectal Cancer	CCLE	TRVQLQPMK	DEG_APCC_DBOX_1	60:68	Mutation altering degron motif	0.6097

Kaplan plot for PAK6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAK6

UniProt ID: Q9NQU5

Entrez ID: 106821730

Protein name: Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAK6 in