DegronMD

Uniprot ID: Q9NQU5

Source protein: Serine/threonine-protein kinase PAK 6

Source gene: PAK6

Class: DEG_APCC_DBOX_1

Location: 60:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5713

ASA_SCORE: 83.1111

COIL: 0.5427

CONS_SCORE: 0.2644

DSS_SCORE: 0.3831

HELIX: 0.0832

FCONS_SCORE: 0.8187

RIG_SCORE: 0.8047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R72L	TCGA-28-5211	GBM	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.2222
p.R72L	DO11016	GBM	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.2222
p.S57L	TCGA-A5-A0G2	UCEC	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.25
p.S57L	TCGA-VQ-A91K	STAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.25
p.S57L	DO51785	STAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.25
p.S57L	DO41235	UCEC	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.25
p.A75T	TCGA-AA-A01P	COAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.A75T	DO8642	COAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.R72W	TCGA-BR-6452	STAD	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.2222
p.R72W	DO38404	STAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.2222
p.P52L	TCGA-DA-A1I5	SKCM	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.P52L	DO37447	SKCM	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.V53M	TCGA-F7-A624	HNSC	TCGA	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.V53M	DO44440	HNSC	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.V53M	SIDM01726	Ewing's Sarcoma	GDSC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.A75V	DO222955	BTCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.M76V	DO229010	COCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.M76V	DO229016	COCA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.M76V	DO234285	ESAD	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.M76V	DO228941	LICA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1111
p.V53L	DO228978	LICA	ICGC	TRVQLQPMK	DEG_APCC_DBOX_1	0.1389
p.P77L	SIDM00492	Glioblastoma	GDSC	TRVQLQPMK	DEG_APCC_DBOX_1	0.0833
p.P77L	ACH-000269	Brain Cancer	CCLE	TRVQLQPMK	DEG_APCC_DBOX_1	0.0833
p.P77L	AM-38	central_nervous_system	COSMIC	TRVQLQPMK	DEG_APCC_DBOX_1	0.0833
p.V62M	ACH-000943	Colon/Colorectal Cancer	CCLE	TRVQLQPMK	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_APCC_DBOX_1	60:68	TRVQLQPMK	APC,CDC20,FZR1	0.5713	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons