DegronMD - Q5H9R7(PPP6R3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K849Q	TCGA-57-1992	OV	TCGA	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6944
p.A851T	TCGA-AG-3894	READ	TCGA	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7139
p.A851T	SIDM00789	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7139
p.A851T	HCT-15	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7139
p.F379L	TCGA-BK-A6W3	UCEC	TCGA	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.3056
p.P843T	TCGA-Y8-A8RZ	KIRP	TCGA	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation substituting flanking lysine	0.2778
p.R385Q	DO222955	BTCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7329
p.R385Q	DO222798	COCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7329
p.R385Q	DO38795	STAD	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7329
p.R385Q	DO41644	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7329
p.V374A	DO233760	GACA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.1667
p.E391D	DO23073	LIHC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.25
p.L376F	DO229218	THCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.2222
p.E388A	DO52414	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7701
p.A398T	DO41578	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.0556
p.E384K	DO41235	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.7022
p.P855S	SIDM02015	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2778
p.A848V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00656	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00846	Cervical Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00654	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00694	Other Solid Cancers	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00878	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00493	Other Solid Cancers	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00032	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00907	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00793	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00257	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM01173	Rhabdomyosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00785	Acute Myeloid Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM01318	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM00641	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.A848V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.3056
p.T845A	SIDM00247	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.T845A	MKN45	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.A851V	SIDM00980	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6936
p.A851V	23132-87	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6936
p.L388V	SIDM01611	Endometrial Carcinoma	GDSC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation altering degron motif	0.5654
p.R376I	ACH-000269	Brain Cancer	CCLE	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.2222
p.R376I	AM-38	central nervous system	COSMIC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.2222
p.C844W	ACH-000283	Brain Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1944
p.A845V	23132-87	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.L372S	HT	haematopoietic and lymphoid tissue	COSMIC	FKYTWNNFL	DEG_MDM2_SWIB_1	380:388	Mutation rewiring degron network	0.1111
p.A845T	HCT-15	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.T839A	MKN45	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556
p.A839V	23132-87	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556
p.A839T	HCT-15	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556
p.A839T	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP6R3

UniProt ID: Q5H9R7

Entrez ID: 55291

Protein name: Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP6R3 in