DegronMD

Uniprot ID: Q5H9R7

Source protein: Serine/threonine-protein phosphatase 6 regulatory subunit 3

Source gene: PPP6R3

Class: DEG_MDM2_SWIB_1

Location: 380:388

E3 ligase: MDM2

DEGRON score: 0.6491

ASA_SCORE: 35.5

COIL: 0.4756

CONS_SCORE: 0.6542

DSS_SCORE: 0.0039

HELIX: 0.4408

FCONS_SCORE: 1.3198

RIG_SCORE: 0.9678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F379L	TCGA-BK-A6W3	UCEC	TCGA	FKYTWNNFL	DEG_MDM2_SWIB_1	0.3056
p.R385Q	DO222955	BTCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7329
p.R385Q	DO222798	COCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7329
p.R385Q	DO38795	STAD	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7329
p.R385Q	DO41644	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7329
p.V374A	DO233760	GACA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.1667
p.E391D	DO23073	LIHC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.25
p.L376F	DO229218	THCA	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.2222
p.E388A	DO52414	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7701
p.A398T	DO41578	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.0556
p.E384K	DO41235	UCEC	ICGC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.7022
p.L388V	SIDM01611	Endometrial Carcinoma	GDSC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.5654
p.R376I	ACH-000269	Brain Cancer	CCLE	FKYTWNNFL	DEG_MDM2_SWIB_1	0.2222
p.R376I	AM-38	central_nervous_system	COSMIC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.2222
p.L372S	HT	haematopoietic_and_lymphoid_tissue	COSMIC	FKYTWNNFL	DEG_MDM2_SWIB_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9R7	Serine/threonine-protein phosphatase 6 regulatory subunit 3	DEG_MDM2_SWIB_1	380:388	FKYTWNNFL	MDM2	0.6491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons