DegronMD - Q8IXM2(BAP18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T72I	TCGA-A5-A0G2	UCEC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.0833
p.T72I	DO41235	UCEC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.0833
p.A114V	TCGA-A5-A0G2	UCEC	TCGA	SSSSVPEA	DEG_COP1_1	119:126	Mutation rewiring degron network	0.1944
p.A114V	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.A114V	DO41235	UCEC	ICGC	SSSSVPEA	DEG_COP1_1	119:126	Mutation rewiring degron network	0.1944
p.A114V	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.S120R	TCGA-A5-A1OF	UCEC	TCGA	SSSSVPEA	DEG_COP1_1	119:126	Mutation altering degron motif	0.7427
p.S120R	TCGA-A5-A1OF	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7427
p.S120R	DO42568	UCEC	ICGC	SSSSVPEA	DEG_COP1_1	119:126	Mutation altering degron motif	0.7427
p.S120R	DO42568	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7427
p.R82C	TCGA-AX-A2HD	UCEC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation altering degron motif	0.719
p.R82C	DO222884	COCA	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation altering degron motif	0.719
p.R82C	DO42608	UCEC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation altering degron motif	0.719
p.S88A	TCGA-AZ-4315	COAD	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.3056
p.S88A	DO8842	COAD	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.3056
p.T79A	TCGA-B0-5113	KIRC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.2778
p.T79A	DO17858	KIRC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.2778
p.L92F	TCGA-EE-A20F	SKCM	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.1944
p.L92F	DO37961	SKCM	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.1944
p.S110L	DO223028	ESCA	ICGC	SSSSVPEA	DEG_COP1_1	119:126	Mutation blocking phosphorylation signal	0.5278
p.S110L	DO223028	ESCA	ICGC	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation blocking phosphorylation signal	0.5833
p.A115D	DO233865	GACA	ICGC	SSSSVPEA	DEG_COP1_1	119:126	Mutation rewiring degron network	0.2222
p.A115D	DO233865	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.2778
p.R71L	SIDM02015	Colorectal Carcinoma	GDSC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.0556
p.R71L	SIDM01619	Endometrial Carcinoma	GDSC	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.0556
p.R71L	ACH-000984	Endometrial/Uterine Cancer	CCLE	KRKVYED	LIG_APCC_ABBAyCdc20_2	81:87	Mutation rewiring degron network	0.0556
p.P116L	SIDM00846	Cervical Carcinoma	GDSC	SSSSVPEA	DEG_COP1_1	119:126	Mutation rewiring degron network	0.25
p.P116L	SIDM00846	Cervical Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.3056
p.P112L	ACH-001547	Lung Cancer	CCLE	SSSSVPEA	DEG_COP1_1	119:126	Mutation rewiring degron network	0.1389
p.P112L	ACH-001547	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAP18

UniProt ID: Q8IXM2

Entrez ID: 124944

Protein name: Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BAP18 in