DegronMD

Uniprot ID: Q8IXM2

Source protein: Chromatin complexes subunit BAP18

Source gene: BAP18

Class: LIG_APCC_ABBAyCdc20_2

Location: 81:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9248

ASA_SCORE: 107.0571

COIL: 0.3961

CONS_SCORE: 0.6415

DSS_SCORE: 0.3269

HELIX: 0.5723

FCONS_SCORE: 1.1021

RIG_SCORE: 0.821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T72I	TCGA-A5-A0G2	UCEC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.T72I	DO41235	UCEC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.R82C	TCGA-AX-A2HD	UCEC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.719
p.R82C	DO222884	COCA	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.719
p.R82C	DO42608	UCEC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.719
p.S88A	TCGA-AZ-4315	COAD	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S88A	DO8842	COAD	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.T79A	TCGA-B0-5113	KIRC	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.T79A	DO17858	KIRC	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.L92F	TCGA-EE-A20F	SKCM	TCGA	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.1944
p.L92F	DO37961	SKCM	ICGC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R71L	SIDM02015	Colorectal Carcinoma	GDSC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.0556
p.R71L	SIDM01619	Endometrial Carcinoma	GDSC	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.0556
p.R71L	ACH-000984	Endometrial/Uterine Cancer	CCLE	KRKVYED	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXM2	Chromatin complexes subunit BAP18	LIG_APCC_ABBAyCdc20_2	81:87	KRKVYED	APC,CDC20,FZR1	0.9248	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons