DegronMD

Uniprot ID: Q8IXM2

Source protein: Chromatin complexes subunit BAP18

Source gene: BAP18

Class: DEG_COP1_1

Location: 119:126

E3 ligase: COP1

DEGRON score: 0.938

ASA_SCORE: 84.6125

COIL: 0.9325

CONS_SCORE: 0.4287

DSS_SCORE: 0.7232

HELIX: 0.0295

FCONS_SCORE: 0.8825

RIG_SCORE: 0.5141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A114V	TCGA-A5-A0G2	UCEC	TCGA	SSSSVPEA	DEG_COP1_1	0.1944
p.A114V	DO41235	UCEC	ICGC	SSSSVPEA	DEG_COP1_1	0.1944
p.S120R	TCGA-A5-A1OF	UCEC	TCGA	SSSSVPEA	DEG_COP1_1	0.7427
p.S120R	DO42568	UCEC	ICGC	SSSSVPEA	DEG_COP1_1	0.7427
p.S110L	DO223028	ESCA	ICGC	SSSSVPEA	DEG_COP1_1	0.5278
p.A115D	DO233865	GACA	ICGC	SSSSVPEA	DEG_COP1_1	0.2222
p.P116L	SIDM00846	Cervical Carcinoma	GDSC	SSSSVPEA	DEG_COP1_1	0.25
p.P112L	ACH-001547	Lung Cancer	CCLE	SSSSVPEA	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXM2	Chromatin complexes subunit BAP18	DEG_COP1_1	119:126	SSSSVPEA	COP1	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons