DegronMD - Q96MN9(ZNF488)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S164I	TCGA-A4-7828	KIRP	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.Q247H	TCGA-AP-A059	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.25
p.S258L	TCGA-AZ-4315	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.S258L	TCGA-DA-A1HV	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.S258L	TCGA-EE-A3AG	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.S258L	TCGA-ZJ-A8QR	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.P249L	TCGA-D9-A4Z3	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.3056
p.P249L	TCGA-EE-A2A2	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.3056
p.V179I	TCGA-EE-A3J7	SKCM	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.5965
p.G190V	TCGA-ER-A2NH	SKCM	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.S254F	TCGA-GF-A6C9	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7982
p.R169L	TCGA-HU-A4GF	STAD	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.25
p.R169L	TCGA-X6-A7W8	SARC	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.25
p.S178L	TCGA-IQ-A61E	HNSC	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6556
p.K165I	TCGA-PQ-A6FN	BLCA	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation substituting flanking lysine	0.25
p.G183R	TCGA-Z2-A8RT	SKCM	TCGA	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.25
p.R178C	DO44042	BLCA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8301
p.R178C	DO37425	SKCM	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8301
p.R178H	DO227536	COCA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.R178H	DO234232	ESAD	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.M187I	DO233686	GACA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1389
p.C170G	DO228655	LICA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2778
p.F185L	DO23222	LINC	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1944
p.R188Q	DO26444	LUSC	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.R188Q	DO34624	PACA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.D182N	DO220906	MELA	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2778
p.S176F	DO51254	SKCM	ICGC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7982
p.G183V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.25
p.G183V	ACH-000875	Lung Cancer	CCLE	ERPELTSVF	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.25
p.A260T	SIDM00045	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.A260T	SIDM01442	Glioma	GDSC	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667
p.A260T	SIDM01619	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1667

Kaplan plot for ZNF488 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF488

UniProt ID: Q96MN9

Entrez ID: 118738

Protein name: Zinc finger protein 488

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF488 in