DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERPELTSVF
Uniprot ID:
Q96MN9
Source protein:
Zinc finger protein 488
Source gene:
ZNF488
Class:
DEG_APCC_DBOX_1
Location:
172:180
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.854
ASA_SCORE:
80.5
COIL:
0.7786
CONS_SCORE:
0.3933
DSS_SCORE:
0.5736
HELIX:
0.1769
FCONS_SCORE:
0.8916
RIG_SCORE:
0.7009
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S164I
TCGA-A4-7828
KIRP
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.1111
p.V179I
TCGA-EE-A3J7
SKCM
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.5965
p.G190V
TCGA-ER-A2NH
SKCM
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.0556
p.R169L
TCGA-HU-A4GF
STAD
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.25
p.R169L
TCGA-X6-A7W8
SARC
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.25
p.S178L
TCGA-IQ-A61E
HNSC
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.6556
p.K165I
TCGA-PQ-A6FN
BLCA
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.25
p.G183R
TCGA-Z2-A8RT
SKCM
TCGA
ERPELTSVF
DEG_APCC_DBOX_1
0.25
p.R178C
DO44042
BLCA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.8301
p.R178C
DO37425
SKCM
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.8301
p.R178H
DO227536
COCA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.8244
p.R178H
DO234232
ESAD
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.8244
p.M187I
DO233686
GACA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.1389
p.C170G
DO228655
LICA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.2778
p.F185L
DO23222
LINC
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.1944
p.R188Q
DO26444
LUSC
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.1111
p.R188Q
DO34624
PACA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.1111
p.D182N
DO220906
MELA
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.2778
p.S176F
DO51254
SKCM
ICGC
ERPELTSVF
DEG_APCC_DBOX_1
0.7982
p.G183V
SIDM00726
Non-Small Cell Lung Carcinoma
GDSC
ERPELTSVF
DEG_APCC_DBOX_1
0.25
p.G183V
ACH-000875
Lung Cancer
CCLE
ERPELTSVF
DEG_APCC_DBOX_1
0.25
Drug responses associated with ZNF488 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERPELTSVF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96MN9
Zinc finger protein 488
DEG_APCC_DBOX_1
172:180
ERPELTSVF
APC,CDC20,FZR1
0.854
More...