DegronMD - Q96JY6(PDLIM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S171C	DO785	BLCA	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation altering degron motif	0.7541
p.R153C	DO223732	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.R153C	DO229456	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.S134I	DO8103	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6389
p.P130L	DO229016	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R169C	DO233766	GACA	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation altering degron motif	0.719
p.I151M	DO25058	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.S144F	DO233299	NACA	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.75
p.R169P	DO32327	OV	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation altering degron motif	0.6401
p.F136V	DO36556	READ	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.P140L	DO37839	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.6471
p.P139S	DO37831	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.6752
p.P165S	DO37406	SKCM	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation rewiring degron network	0.25
p.S137L	DO50287	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.7222
p.P162Q	DO47491	SKCM	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation rewiring degron network	0.1667
p.S129N	DO47337	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5
p.G163S	DO48626	SKCM	ICGC	DRLSYSGRP	CBL_PTK	168:176	Mutation rewiring degron network	0.1944
p.S152N	DO47867	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.L164F	ACH-001982	Metastasis	CCLE	DRLSYSGRP	CBL_PTK	168:176	Mutation rewiring degron network	0.2222
p.T141P	NCI-H1944	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7031
p.T141P	RCC-MF	kidney	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7031
p.T141P	DOV13	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7031
p.T141P	SIMA	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7031
p.T141P	TOV-112D	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7031
p.R133C	C3A	liver	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.P132L	G-361	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.P132L	SNU-C1	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.P150L	RKO	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389

Kaplan plot for PDLIM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDLIM2

UniProt ID: Q96JY6

Entrez ID: 64236

Protein name: PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDLIM2 in