DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DRLSYSGRP
Uniprot ID:
Q96JY6
Source protein:
PDZ and LIM domain protein 2
Source gene:
PDLIM2
Class:
CBL_PTK
Location:
168:176
E3 ligase:
CBL
DEGRON score:
0.9826
ASA_SCORE:
74.2778
COIL:
0.7596
CONS_SCORE:
0.397
DSS_SCORE:
0.53
HELIX:
0.1548
FCONS_SCORE:
0.9839
RIG_SCORE:
0.6688
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S171C
DO785
BLCA
ICGC
DRLSYSGRP
CBL_PTK
0.7541
p.R169C
DO233766
GACA
ICGC
DRLSYSGRP
CBL_PTK
0.719
p.R169P
DO32327
OV
ICGC
DRLSYSGRP
CBL_PTK
0.6401
p.P165S
DO37406
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.25
p.P162Q
DO47491
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.1667
p.G163S
DO48626
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.1944
p.L164F
ACH-001982
Metastasis
CCLE
DRLSYSGRP
CBL_PTK
0.2222
Drug responses associated with PDLIM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRLSYSGRP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JY6
PDZ and LIM domain protein 2
CBL_PTK
168:176
DRLSYSGRP
CBL
0.9826
More...