DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DRLSYSGRP
Uniprot ID:
Q96JY6
Source protein:
PDZ and LIM domain protein 2
Source gene:
PDLIM2
Class:
CBL_PTK
Location:
168:176
E3 ligase:
CBL
DEGRON score:
0.9826
ASA_SCORE:
74.2778
COIL:
0.7596
CONS_SCORE:
0.397
DSS_SCORE:
0.53
HELIX:
0.1548
FCONS_SCORE:
0.9839
RIG_SCORE:
0.6688
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S171C
DO785
BLCA
ICGC
DRLSYSGRP
CBL_PTK
0.7541
p.R169C
DO233766
GACA
ICGC
DRLSYSGRP
CBL_PTK
0.719
p.R169P
DO32327
OV
ICGC
DRLSYSGRP
CBL_PTK
0.6401
p.P165S
DO37406
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.25
p.L164F
ACH-001982
Metastasis
CCLE
DRLSYSGRP
CBL_PTK
0.2222
p.G163S
DO48626
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.1944
p.P162Q
DO47491
SKCM
ICGC
DRLSYSGRP
CBL_PTK
0.1667
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Drug responses associated with PDLIM2 mutations
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Sample
Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of DRLSYSGRP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JY6
PDZ and LIM domain protein 2
CBL_PTK
168:176
DRLSYSGRP
CBL
0.9826
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