DegronMD - Q8NC96(NECAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H209R	TCGA-2Y-A9GY	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.H209R	DO219515	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.P236S	TCGA-55-8205	LUAD	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.6752
p.P236S	DO48884	LUAD	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.6752
p.P236T	TCGA-66-2785	LUSC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7031
p.P236T	DO26520	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7031
p.A241V	TCGA-94-8490	LUSC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.5825
p.A241V	DO52021	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.5825
p.S233Y	TCGA-AX-A0J0	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233Y	TCGA-EO-A3AV	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233Y	TCGA-EO-A3B0	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233Y	DO219773	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233Y	DO52412	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233Y	DO41133	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.V195I	TCGA-B5-A3FC	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.V195I	DO41871	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.P190L	TCGA-BR-4201	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.P190L	DO38707	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.P190L	ACH-001414	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.A205V	TCGA-BR-8371	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.A205V	DO47950	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.P191S	TCGA-D3-A3MV	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.P191S	DO37727	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.N249S	TCGA-DD-A3A8	LIHC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.1667
p.N249S	DO44883	LIHC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.1667
p.P189L	TCGA-EE-A2GC	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556
p.P189L	DO37839	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556
p.S233F	TCGA-EO-A22X	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233F	DO44808	LICA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.S233F	DO43907	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.25
p.K194N	TCGA-IA-A83W	KIRP	TCGA	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation substituting flanking lysine	0.3056
p.K194N	DO51566	KIRP	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation substituting flanking lysine	0.3056
p.G253R	TCGA-V4-A9EZ	UVM	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.0556
p.S203L	DO218173	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.7667
p.N208S	DO229333	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.N208S	SIDM00057	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.N208S	SIDM00552	Rhabdomyosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.N208S	ACH-000607	Rhabdoid	CCLE	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.N208S	KYM-1	soft tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.T238M	DO233156	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.6312
p.A241T	DO233089	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.6028
p.P198H	DO233245	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.3056
p.N249I	DO233941	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.1667
p.H209D	DO230556	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.L251F	DO224539	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.1111
p.L251F	DO231010	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.1111
p.T243A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7139
p.T243A	ACH-000995	Leukemia	CCLE	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7139
p.T243A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7139
p.P199S	SIDM01175	Other Sarcomas	GDSC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6752
p.P199S	ACH-001566	Skin Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6752
p.P199S	ACH-002309	Sarcoma	CCLE	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6752
p.P199S	SW684	soft tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6752
p.V210I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.V210I	ACH-002062	Lymphoma	CCLE	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.V210I	SLVL	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.D232V	ACH-001645	Skin Cancer	CCLE	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.2222
p.T239A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation altering degron motif	0.7139
p.D247V	SNU-407	large intestine	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	236:243	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NECAP1

UniProt ID: Q8NC96

Entrez ID: 25977

Protein name: Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NECAP1 in