DegronMD

Uniprot ID: Q8NC96

Source protein: Adaptin ear-binding coat-associated protein 1

Source gene: NECAP1

Class: DEG_SCF_FBW7_1

Location: 236:243

E3 ligase: FBXW7

DEGRON score: 0.8926

ASA_SCORE: 88.65

COIL: 0.9625

CONS_SCORE: 0.4701

DSS_SCORE: 0.5472

HELIX: 0.0129

FCONS_SCORE: 0.9567

RIG_SCORE: 0.6703

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P236S	TCGA-55-8205	LUAD	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.6752
p.P236S	DO48884	LUAD	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.6752
p.P236T	TCGA-66-2785	LUSC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.7031
p.P236T	DO26520	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.7031
p.A241V	TCGA-94-8490	LUSC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.5825
p.A241V	DO52021	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.5825
p.S233Y	TCGA-AX-A0J0	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233Y	TCGA-EO-A3AV	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233Y	TCGA-EO-A3B0	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233Y	DO219773	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233Y	DO52412	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233Y	DO41133	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.N249S	TCGA-DD-A3A8	LIHC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.1667
p.N249S	DO44883	LIHC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.1667
p.S233F	TCGA-EO-A22X	UCEC	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233F	DO44808	LICA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.S233F	DO43907	UCEC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.25
p.G253R	TCGA-V4-A9EZ	UVM	TCGA	PVTTPAPT	DEG_SCF_FBW7_1	0.0556
p.T238M	DO233156	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.6312
p.A241T	DO233089	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.6028
p.N249I	DO233941	GACA	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.1667
p.L251F	DO224539	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.1111
p.L251F	DO231010	LUSC	ICGC	PVTTPAPT	DEG_SCF_FBW7_1	0.1111
p.T243A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PVTTPAPT	DEG_SCF_FBW7_1	0.7139
p.T243A	ACH-000995	Leukemia	CCLE	PVTTPAPT	DEG_SCF_FBW7_1	0.7139
p.T243A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	0.7139
p.D232V	ACH-001645	Skin Cancer	CCLE	PVTTPAPT	DEG_SCF_FBW7_1	0.2222
p.T239A	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	0.7139
p.D247V	SNU-407	large_intestine	COSMIC	PVTTPAPT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTPAPT

Degron related mutations and impact score

Drug responses associated with NECAP1 mutations

All proteins holding degron of PVTTPAPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NC96	Adaptin ear-binding coat-associated protein 1	DEG_SCF_FBW7_1	236:243	PVTTPAPT	FBXW7	0.8926	More...