DegronMD - Q7RTM1(OTOP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R532C	TCGA-D3-A8GM	SKCM	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.R532C	TCGA-YG-AA3N	SKCM	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.R532C	DO50288	SKCM	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.R532C	DO51298	SKCM	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.P531L	TCGA-DU-6407	LGG	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1111
p.P531L	DO22295	LGG	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1111
p.F551L	TCGA-JW-A5VL	CESC	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2222
p.F551L	DO49976	CESC	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2222
p.R532H	TCGA-VQ-A8P2	STAD	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.R532H	DO233128	GACA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.R532H	DO51761	STAD	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.S38C	DO222541	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO222716	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO222916	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO222910	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO222926	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23128	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23126	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23178	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23188	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23454	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23424	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23378	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.S38C	DO23354	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.2222
p.R529C	DO233254	GACA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.0556
p.S556L	DO228950	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.0833
p.S556L	DO229051	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.0833
p.I555T	DO228950	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1111
p.G21E	DO222683	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.G536A	SIDM01139	Pancreatic Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00933	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00798	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00684	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00454	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM01171	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00776	Colorectal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00633	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00860	Head and Neck Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00263	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00928	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00156	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00538	Esophageal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00879	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00858	Osteosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00254	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00907	Burkitt's Lymphoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00930	Osteosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM01042	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00261	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00083	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00257	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM00115	Head and Neck Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM01173	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.G536A	SIDM01475	Ovarian Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.A43V	SIDM00672	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.A43V	SIDM00454	Rhabdomyosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.A43V	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.A43V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.A43V	SIDM01591	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.0833
p.L552F	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1944
p.L552F	SIDM00263	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1944
p.L552F	SIDM01247	Burkitt's Lymphoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1944
p.L552F	SIDM00143	Small Cell Lung Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1944
p.A538T	SIDM00217	Colorectal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.3056
p.A538T	SNU-1040	large intestine	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.3056
p.N545D	SIDM01611	Endometrial Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation altering degron motif	0.5821
p.N545D	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation altering degron motif	0.5821
p.S41F	ACH-001616	Lymphoma	CCLE	PPSSS	DEG_SPOP_SBC_1	30:34	Mutation rewiring degron network	0.1389
p.N537K	GA-10	haematopoietic and lymphoid tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	NB7	autonomic ganglia	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	CAL-72	bone	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	PANC-02-03	pancreas	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	NB13	autonomic ganglia	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	NCI-H1341	lung	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	RH-18	soft tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537K	PCI-6A	upper aerodigestive tract	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778
p.N537H	RH-18	soft tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTOP1

UniProt ID: Q7RTM1

Entrez ID: 133060

Protein name: Proton channel OTOP1 (Otopetrin-1) (hOtop1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTOP1 in