DegronMD

Uniprot ID: Q7RTM1

Source protein: Proton channel OTOP1

Source gene: OTOP1

Class: DEG_APCC_DBOX_1

Location: 539:547

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7748

ASA_SCORE: 71.2667

COIL: 0.1208

CONS_SCORE: 0.6734

DSS_SCORE: 0.0408

HELIX: 0.8802

FCONS_SCORE: 1.4829

RIG_SCORE: 0.9183

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R532C	TCGA-D3-A8GM	SKCM	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R532C	TCGA-YG-AA3N	SKCM	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R532C	DO50288	SKCM	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R532C	DO51298	SKCM	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.P531L	TCGA-DU-6407	LGG	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	0.1111
p.P531L	DO22295	LGG	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1111
p.F551L	TCGA-JW-A5VL	CESC	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	0.2222
p.F551L	DO49976	CESC	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2222
p.R532H	TCGA-VQ-A8P2	STAD	TCGA	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R532H	DO233128	GACA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R532H	DO51761	STAD	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1389
p.R529C	DO233254	GACA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.0556
p.S556L	DO228950	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.0833
p.S556L	DO229051	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.0833
p.I555T	DO228950	LICA	ICGC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1111
p.G536A	SIDM01139	Pancreatic Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00933	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00798	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00684	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00454	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM01171	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00776	Colorectal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00633	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00860	Head and Neck Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00263	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00928	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00156	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00538	Esophageal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00879	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00858	Osteosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00254	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00907	Burkitt's Lymphoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00930	Osteosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM01042	Breast Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00261	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00083	Glioblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00257	Neuroblastoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM00115	Head and Neck Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM01173	Rhabdomyosarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.G536A	SIDM01475	Ovarian Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.25
p.L552F	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1944
p.L552F	SIDM00263	Ewing's Sarcoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1944
p.L552F	SIDM01247	Burkitt's Lymphoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1944
p.L552F	SIDM00143	Small Cell Lung Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.1944
p.A538T	SIDM00217	Colorectal Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.3056
p.A538T	SNU-1040	large_intestine	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.3056
p.N545D	SIDM01611	Endometrial Carcinoma	GDSC	KRKVLRNIA	DEG_APCC_DBOX_1	0.5821
p.N545D	ACH-000996	Endometrial/Uterine Cancer	CCLE	KRKVLRNIA	DEG_APCC_DBOX_1	0.5821
p.N537K	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	NB7	autonomic_ganglia	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	CAL-72	bone	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	PANC-02-03	pancreas	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	NB13	autonomic_ganglia	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	NCI-H1341	lung	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	RH-18	soft_tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537K	PCI-6A	upper_aerodigestive_tract	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778
p.N537H	RH-18	soft_tissue	COSMIC	KRKVLRNIA	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRKVLRNIA

Degron related mutations and impact score

Drug responses associated with OTOP1 mutations

All proteins holding degron of KRKVLRNIA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7RTM1	Proton channel OTOP1	DEG_APCC_DBOX_1	539:547	KRKVLRNIA	APC,CDC20,FZR1	0.7748	More...