DegronMD - Q96SU4(OSBPL9)

OSBPL9

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q262E	TCGA-17-Z026	LUAD	TCGA	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.25
p.Q262E	TCGA-17-Z026	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.25
p.P275Q	TCGA-18-3414	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1667
p.R245C	TCGA-63-A5MM	LUSC	TCGA	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.0833
p.P276L	TCGA-6A-AB49	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.H261L	TCGA-A2-A1FZ	BRCA	TCGA	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation blocking phosphorylation signal	0.7222
p.H261L	TCGA-A2-A1FZ	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation blocking phosphorylation signal	0.6667
p.P253S	TCGA-XF-A9ST	BLCA	TCGA	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.3056
p.L253V	KYSE-410	oesophagus	COSMIC	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.3056
p.L270V	KYSE-410	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.3056
p.P271S	NCI-H1770	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2778
p.L257V	KYSE-410	oesophagus	COSMIC	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6765
p.H246P	EM-2	haematopoietic and lymphoid tissue	COSMIC	PTPNST	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1111
p.P267S	NCI-H1770	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.6752

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*NOTE: the Kaplan plots were collected from OncoLnc