DegronMD

Uniprot ID: Q96SU4

Source protein: Oxysterol-binding protein-related protein 9

Source gene: OSBPL9

Class: DEG_SCF_FBW7_1

Location: 254:259

E3 ligase: FBXW7

DEGRON score: 0.9832

ASA_SCORE: 79.9

COIL: 0.8662

CONS_SCORE: 0.4193

DSS_SCORE: 0.7889

HELIX: 0.0343

FCONS_SCORE: 1.0198

RIG_SCORE: 0.5043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q262E	TCGA-17-Z026	LUAD	TCGA	PTPNST	DEG_SCF_FBW7_1	0.25
p.R245C	TCGA-63-A5MM	LUSC	TCGA	PTPNST	DEG_SCF_FBW7_1	0.0833
p.H261L	TCGA-A2-A1FZ	BRCA	TCGA	PTPNST	DEG_SCF_FBW7_1	0.7222
p.P253S	TCGA-XF-A9ST	BLCA	TCGA	PTPNST	DEG_SCF_FBW7_1	0.3056
p.L253V	KYSE-410	oesophagus	COSMIC	PTPNST	DEG_SCF_FBW7_1	0.3056
p.L257V	KYSE-410	oesophagus	COSMIC	PTPNST	DEG_SCF_FBW7_1	0.6765
p.H246P	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PTPNST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SU4	Oxysterol-binding protein-related protein 9	DEG_SCF_FBW7_1	254:259	PTPNST	FBXW7	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons