DegronMD

Uniprot ID: Q49AJ0

Source protein: Protein FAM135B

Source gene: FAM135B

Class: DEG_APCC_DBOX_1

Location: 588:596

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7486

ASA_SCORE: 86.7333

COIL: 0.7909

CONS_SCORE: 0.2628

DSS_SCORE: 0.4552

HELIX: 0.1061

FCONS_SCORE: 1.0738

RIG_SCORE: 0.73

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S593R	TCGA-43-A56U	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.6316
p.S593R	DO49083	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.6316
p.I605F	TCGA-49-AARQ	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.0833
p.I605F	DO51189	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0833
p.D588N	TCGA-55-7994	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.5821
p.D588N	DO45311	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.5821
p.D588N	SIDM00032	Bladder Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.5821
p.Q602K	TCGA-56-1622	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1667
p.Q602K	TCGA-BH-A0B6	BRCA	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1667
p.Q602K	DO2641	BRCA	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1667
p.Q602K	DO26461	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1667
p.H601Q	TCGA-56-1622	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.H601Q	DO26461	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.Y585N	TCGA-58-A46M	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.25
p.Y585N	DO45485	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.25
p.S606Y	TCGA-63-A5MT	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606Y	DO219163	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	TCGA-86-8359	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	TCGA-AX-A2HC	UCEC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	TCGA-EB-A44O	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	DO25817	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	DO47272	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S606F	DO41572	UCEC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.G598V	TCGA-97-8179	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G598V	DO25709	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	TCGA-BF-AAP1	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	DO219464	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	SIDM01175	Other Sarcomas	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	SIDM00290	Gastric Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	ACH-000847	Gastric Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	ACH-002309	Sarcoma	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	SW684	soft_tissue	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586E	HGC-27	stomach	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.S581C	TCGA-CV-6961	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1389
p.S581C	DO14566	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1389
p.R589K	TCGA-CV-A468	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.7237
p.R589K	TCGA-EE-A2GJ	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.7237
p.R589K	DO52070	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.7237
p.R589K	DO37746	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.7237
p.A604V	TCGA-D6-6516	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.A604V	DO15623	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.K594N	TCGA-D7-A4YU	STAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.5806
p.K594N	DO47761	STAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.5806
p.L592I	TCGA-DD-A73F	LIHC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.7174
p.L592I	DO48587	LIHC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.7174
p.G586R	TCGA-EE-A20C	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586R	DO222775	MELA	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G586R	DO47665	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.2778
p.G599E	TCGA-EE-A2GJ	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.25
p.G599E	DO37746	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.25
p.D583N	TCGA-FA-A7Q1	DLBC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.D583N	DO219890	DLBC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.D583Y	TCGA-G5-6235	READ	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.D583Y	DO36612	READ	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1944
p.A604T	TCGA-NC-A5HQ	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.A604T	DO219201	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.S578N	SIDM00773	Non-Cancerous	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S578N	SIDM00210	Ovarian Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S578N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.S578N	SIDM00774	Breast Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.0556
p.R589M	SIDM01120	Other Solid Cancers	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.8632
p.R589M	ACH-002174	Lung Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	0.8632
p.R589M	NCI-H720	lung	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	0.8632
p.A604S	SIDM01045	Endometrial Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.A604S	ACH-000978	Endometrial/Uterine Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.A604S	EN	endometrium	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	0.1111
p.L587F	ACH-001407	Bladder Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRTGLSKVV

Degron related mutations and impact score

Drug responses associated with FAM135B mutations

All proteins holding degron of DRTGLSKVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49AJ0	Protein FAM135B	DEG_APCC_DBOX_1	588:596	DRTGLSKVV	APC,CDC20,FZR1	0.7486	More...