DegronMD

Uniprot ID: O00221

Source protein: NF-kappa-B inhibitor epsilon

Source gene: NFKBIE

Class: DEG_APCC_DBOX_1

Location: 234:242

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6364

ASA_SCORE: 52.2222

COIL: 0.5472

CONS_SCORE: 0.4423

DSS_SCORE: 0.5394

HELIX: 0.4113

FCONS_SCORE: 1.0486

RIG_SCORE: 0.7084

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L232M	SNU-1040	large_intestine	COSMIC	PRLPLPHVG	DEG_APCC_DBOX_1	0.2778
p.A251T	TCGA-GS-A9TZ	DLBC	TCGA	PRLPLPHVG	DEG_APCC_DBOX_1	0.0833
p.A251T	DO219918	DLBC	ICGC	PRLPLPHVG	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_APCC_DBOX_1	234:242	PRLPLPHVG	APC,CDC20,FZR1	0.6364	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons