DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PRLPLPHVG
Uniprot ID:
O00221
Source protein:
NF-kappa-B inhibitor epsilon
Source gene:
NFKBIE
Class:
DEG_APCC_DBOX_1
Location:
234:242
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6364
ASA_SCORE:
52.2222
COIL:
0.5472
CONS_SCORE:
0.4423
DSS_SCORE:
0.5394
HELIX:
0.4113
FCONS_SCORE:
1.0486
RIG_SCORE:
0.7084
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A251T
TCGA-GS-A9TZ
DLBC
TCGA
PRLPLPHVG
DEG_APCC_DBOX_1
0.0833
p.A251T
DO219918
DLBC
ICGC
PRLPLPHVG
DEG_APCC_DBOX_1
0.0833
p.L232M
SNU-1040
large_intestine
COSMIC
PRLPLPHVG
DEG_APCC_DBOX_1
0.2778
Drug responses associated with NFKBIE mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRLPLPHVG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00221
NF-kappa-B inhibitor epsilon
DEG_APCC_DBOX_1
234:242
PRLPLPHVG
APC,CDC20,FZR1
0.6364
More...