DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SIAH_1

Location: 1187:1195

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9955

ASA_SCORE: 97.5889

COIL: 0.9609

CONS_SCORE: 0.3912

DSS_SCORE: 0.7218

HELIX: 0.0219

FCONS_SCORE: 0.9809

RIG_SCORE: 0.6617

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1200M	TCGA-66-2744	LUSC	TCGA	EPRAPVAPT	DEG_SIAH_1	0.1944
p.I1200M	DO27025	LUSC	ICGC	EPRAPVAPT	DEG_SIAH_1	0.1944
p.R1189H	TCGA-AX-A2HD	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	TCGA-B5-A3FC	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	DO41871	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	DO42608	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	SIDM01090	Colorectal Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	ACH-000943	Colon/Colorectal Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	0.7133
p.R1189H	RKO	large_intestine	COSMIC	EPRAPVAPT	DEG_SIAH_1	0.7133
p.G1179D	TCGA-B5-A3FA	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	0.1111
p.G1179D	DO52402	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	0.1111
p.V1205I	TCGA-D1-A103	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	0.0556
p.V1205I	DO42312	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	0.0556
p.Q1178H	TCGA-LN-A9FP	ESCA	TCGA	EPRAPVAPT	DEG_SIAH_1	0.0833
p.P1194H	DO229054	LICA	ICGC	EPRAPVAPT	DEG_SIAH_1	0.7694
p.Q1178K	DO229009	LICA	ICGC	EPRAPVAPT	DEG_SIAH_1	0.0833
p.P1191L	SIDM00330	Neuroblastoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6471
p.P1191L	SIDM00050	Chondrosarcoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6471
p.P1191L	SIDM00870	Breast Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6471
p.P1191L	SIDM01679	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6471
p.P1191L	SIDM01504	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6471
p.P1188S	SIDM00878	Breast Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6752
p.P1188S	ACH-000930	Breast Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	0.6752
p.P1188S	HCC1569	breast	COSMIC	EPRAPVAPT	DEG_SIAH_1	0.6752
p.A1193S	SIDM00292	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	0.6477
p.A1193S	ACH-002077	Lung Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	0.6477
p.A1193S	LU-165	lung	COSMIC	EPRAPVAPT	DEG_SIAH_1	0.6477
p.L1199V	ACH-000923	Lymphoma	CCLE	EPRAPVAPT	DEG_SIAH_1	0.2222
p.P1197H	ACH-000985	Colon/Colorectal Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPRAPVAPT

Degron related mutations and impact score

Drug responses associated with KMT2D mutations

All proteins holding degron of EPRAPVAPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SIAH_1	1187:1195	EPRAPVAPT	SIAH1,SIAH2,SIAH3	0.9955	More...