DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_2

Location: 2838:2844

E3 ligase: FBXW7

DEGRON score: 0.9864

ASA_SCORE: 89.3286

COIL: 0.9646

CONS_SCORE: 0.4308

DSS_SCORE: 0.6445

HELIX: 0.0226

FCONS_SCORE: 1.1075

RIG_SCORE: 0.6102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2849V	TCGA-AX-A2HC	UCEC	TCGA	PSTPGPE	DEG_SCF_FBW7_2	0.1944
p.A2849V	DO41572	UCEC	ICGC	PSTPGPE	DEG_SCF_FBW7_2	0.1944
p.R2847C	DO233903	GACA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	0.25
p.P2853Q	DO229028	LICA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	0.0833
p.Q2848K	DO229026	LICA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	0.2222
p.S2828F	DO222775	MELA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	0.0556
p.G2846C	SIDM00282	Colorectal Carcinoma	GDSC	PSTPGPE	DEG_SCF_FBW7_2	0.2778
p.G2846C	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPGPE	DEG_SCF_FBW7_2	0.2778
p.G2846C	CW-2	large_intestine	COSMIC	PSTPGPE	DEG_SCF_FBW7_2	0.2778
p.P2841L	SIDM00487	Colorectal Carcinoma	GDSC	PSTPGPE	DEG_SCF_FBW7_2	0.7582
p.P2841L	ACH-000963	Colon/Colorectal Cancer	CCLE	PSTPGPE	DEG_SCF_FBW7_2	0.7582
p.P2841L	CCK-81	large_intestine	COSMIC	PSTPGPE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_2	2838:2844	PSTPGPE	FBXW7	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons