DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_2

Location: 377:384

E3 ligase: FBXW7

DEGRON score: 0.8825

ASA_SCORE: 82.1

COIL: 0.9255

CONS_SCORE: 0.2559

DSS_SCORE: 0.7045

HELIX: 0.0399

FCONS_SCORE: 0.8545

RIG_SCORE: 0.5996

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P381T	DO229027	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.7031
p.V390A	TCGA-BR-4368	STAD	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	0.1667
p.V390A	DO38715	STAD	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1667
p.R371G	TCGA-CV-7435	HNSC	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	0.1667
p.R371G	DO14918	HNSC	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1667
p.V390I	DO228542	GACA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1667
p.S370R	TCGA-A5-A1OJ	UCEC	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	0.1389
p.S370R	DO229029	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1389
p.S370R	DO42496	UCEC	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1389
p.A391E	DO229035	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_2	377:384	PGDTPTDE	FBXW7	0.8825	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons