DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_1

Location: 4305:4312

E3 ligase: FBXW7

DEGRON score: 0.9521

ASA_SCORE: 103.3875

COIL: 0.9823

CONS_SCORE: 0.4512

DSS_SCORE: 0.8534

HELIX: 0.006

FCONS_SCORE: 1.1934

RIG_SCORE: 0.4795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4319I	TCGA-AP-A1E0	UCEC	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.R4319I	TCGA-MP-A4TF	LUAD	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.R4319I	DO45316	LUAD	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.R4319I	DO43154	UCEC	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.L4302F	TCGA-EO-A22U	UCEC	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	0.25
p.L4302F	DO43755	UCEC	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	0.25
p.Q4322K	DO229037	LICA	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	0.0556
p.V4301A	SIDM02059	Colorectal Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.2222
p.V4305I	SIDM00427	Ewing's Sarcoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.5965
p.V4305I	SIDM00506	Small Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.5965
p.V4305I	SIDM00795	Melanoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.5965
p.V4305I	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.5965
p.Q4315E	SIDM01148	Plasma Cell Myeloma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.25
p.Q4315E	ACH-000050	Myeloma	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	0.25
p.Q4315E	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	0.25
p.S4297F	SIDM01148	Plasma Cell Myeloma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.1111
p.S4297F	ACH-000050	Myeloma	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	0.1111
p.S4297F	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	0.1111
p.T4298I	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.T4298I	ACH-000675	Lung Cancer	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	0.1389
p.T4298I	NCI-H1734	lung	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_1	4305:4312	VHPTPPPS	FBXW7	0.9521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons