DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: LIG_APCC_ABBA_1

Location: 600:605

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9867

ASA_SCORE: 111.8333

COIL: 0.9647

CONS_SCORE: 0.345

DSS_SCORE: 0.7954

HELIX: 0.0197

FCONS_SCORE: 1.0087

RIG_SCORE: 0.5608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R598H	TCGA-A6-6781	COAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.R598H	TCGA-JY-A93D	ESCA	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.R598H	TCGA-XK-AAIW	PRAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.R598H	DO8447	COAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.R598H	DO51407	PRAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.P602S	TCGA-AP-A059	UCEC	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.6752
p.P602S	DO41361	UCEC	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.6752
p.R598C	TCGA-F1-6177	STAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.R598C	DO38727	STAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.2778
p.S606F	TCGA-GN-A263	SKCM	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.S606F	DO37766	SKCM	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.L599V	DO51527	PACA	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.S597F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	FPPFEE	LIG_APCC_ABBA_1	0.25
p.S597F	ACH-000960	Leukemia	CCLE	FPPFEE	LIG_APCC_ABBA_1	0.25
p.S597F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	FPPFEE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	LIG_APCC_ABBA_1	600:605	FPPFEE	APC,CDC20,FZR1	0.9867	More...
Q00056	Homeobox protein Hox-A4	LIG_APCC_ABBA_1	17:22	FPPFEE	APC,CDC20,FZR1	0.7868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons