DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLTPRAS
Uniprot ID:
O14686
Source protein:
Histone-lysine N-methyltransferase 2D
Source gene:
KMT2D
Class:
DEG_SCF_FBW7_1
Location:
2330:2336
E3 ligase:
FBXW7
DEGRON score:
0.9972
ASA_SCORE:
94.6714
COIL:
0.9566
CONS_SCORE:
0.4117
DSS_SCORE:
0.6601
HELIX:
0.026
FCONS_SCORE:
1.0742
RIG_SCORE:
0.681
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A2329T
TCGA-AX-A063
UCEC
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.A2329T
DO42201
UCEC
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.R2334Q
TCGA-BR-4201
STAD
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.6218
p.R2334Q
DO38707
STAD
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.6218
p.D2325N
TCGA-EA-A3HQ
CESC
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.1944
p.D2325N
DO6317
CESC
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.1944
p.R2334L
TCGA-EE-A2GH
SKCM
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.7316
p.R2334L
DO37643
SKCM
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.7316
p.Q2337E
TCGA-IR-A3LL
CESC
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.Q2337E
DO44362
CESC
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.P2340S
TCGA-N5-A4RD
UCS
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.2222
p.R2334W
TCGA-VS-A959
CESC
TCGA
PLTPRAS
DEG_SCF_FBW7_1
0.7523
p.R2334W
DO51640
CESC
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.7523
p.K2322E
DO9700
COAD
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.2222
p.P2343L
DO233784
GACA
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.1389
p.P2343L
DO233918
GACA
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.1389
p.T2323K
DO228952
LICA
ICGC
PLTPRAS
DEG_SCF_FBW7_1
0.5833
p.T2323A
SIDM00845
Burkitt's Lymphoma
GDSC
PLTPRAS
DEG_SCF_FBW7_1
0.5833
p.T2323A
SIDM00035
Thyroid Gland Carcinoma
GDSC
PLTPRAS
DEG_SCF_FBW7_1
0.5833
p.T2323A
SIDM00461
Acute Myeloid Leukemia
GDSC
PLTPRAS
DEG_SCF_FBW7_1
0.5833
p.T2323A
ACH-000786
Lymphoma
CCLE
PLTPRAS
DEG_SCF_FBW7_1
0.5833
p.Q2337K
SIDM01148
Plasma Cell Myeloma
GDSC
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.Q2337K
ACH-000050
Myeloma
CCLE
PLTPRAS
DEG_SCF_FBW7_1
0.3056
p.Q2337K
NCI-H929
haematopoietic_and_lymphoid_tissue
COSMIC
PLTPRAS
DEG_SCF_FBW7_1
0.3056
Drug responses associated with KMT2D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLTPRAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14686
Histone-lysine N-methyltransferase 2D
DEG_SCF_FBW7_1
2330:2336
PLTPRAS
FBXW7
0.9972
More...