DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_1

Location: 4626:4633

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 81.9625

COIL: 0.9523

CONS_SCORE: 0.6544

DSS_SCORE: 0.8106

HELIX: 0.0291

FCONS_SCORE: 1.3252

RIG_SCORE: 0.5303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V4639A	DO229227	THCA	ICGC	LPPTPPPS	DEG_SCF_FBW7_1	0.1667
p.L4616P	SIDM00334	Endometrial Carcinoma	GDSC	LPPTPPPS	DEG_SCF_FBW7_1	0.0556
p.L4616P	ACH-000879	Endometrial/Uterine Cancer	CCLE	LPPTPPPS	DEG_SCF_FBW7_1	0.0556
p.P4628L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPPTPPPS	DEG_SCF_FBW7_1	0.6471
p.P4628L	ACH-000866	Lung Cancer	CCLE	LPPTPPPS	DEG_SCF_FBW7_1	0.6471
p.P4628L	NCI-H1048	lung	COSMIC	LPPTPPPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_1	4626:4633	LPPTPPPS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons