DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: CBL_PTK

Location: 2448:2454

E3 ligase: CBL

DEGRON score: 0.9544

ASA_SCORE: 99.1286

COIL: 0.9683

CONS_SCORE: 0.4069

DSS_SCORE: 0.8062

HELIX: 0.0144

FCONS_SCORE: 0.9083

RIG_SCORE: 0.5265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2452H	TCGA-06-5416	GBM	TCGA	DPYSRPP	CBL_PTK	0.7133
p.R2452H	DO10880	GBM	ICGC	DPYSRPP	CBL_PTK	0.7133
p.R2443H	TCGA-AX-A2HC	UCEC	TCGA	DPYSRPP	CBL_PTK	0.1944
p.R2443H	DO41572	UCEC	ICGC	DPYSRPP	CBL_PTK	0.1944
p.V2440I	TCGA-CG-5721	STAD	TCGA	DPYSRPP	CBL_PTK	0.1111
p.V2440I	TCGA-G7-6790	KIRP	TCGA	DPYSRPP	CBL_PTK	0.1111
p.V2440I	DO20888	KIRP	ICGC	DPYSRPP	CBL_PTK	0.1111
p.V2440I	DO38192	STAD	ICGC	DPYSRPP	CBL_PTK	0.1111
p.R2460L	TCGA-J9-A52C	PRAD	TCGA	DPYSRPP	CBL_PTK	0.1667
p.R2460L	DO51343	PRAD	ICGC	DPYSRPP	CBL_PTK	0.1667
p.A2464D	DO229025	LICA	ICGC	DPYSRPP	CBL_PTK	0.0556
p.S2451F	SIDM00973	Melanoma	GDSC	DPYSRPP	CBL_PTK	0.7982
p.S2451F	ACH-000827	Skin Cancer	CCLE	DPYSRPP	CBL_PTK	0.7982
p.S2451F	WM793B	skin	COSMIC	DPYSRPP	CBL_PTK	0.7982
p.R2452S	SIDM00973	Melanoma	GDSC	DPYSRPP	CBL_PTK	0.6316
p.R2452S	ACH-000827	Skin Cancer	CCLE	DPYSRPP	CBL_PTK	0.6316
p.R2452S	WM793B	skin	COSMIC	DPYSRPP	CBL_PTK	0.6316
p.P2457L	SIDM00313	Hodgkin's Lymphoma	GDSC	DPYSRPP	CBL_PTK	0.25
p.P2457L	ACH-000702	Lymphoma	CCLE	DPYSRPP	CBL_PTK	0.25
p.P2457L	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	DPYSRPP	CBL_PTK	0.25
p.R2456C	SIDM01609	Endometrial Carcinoma	GDSC	DPYSRPP	CBL_PTK	0.2778
p.R2456C	SIDM01617	Endometrial Carcinoma	GDSC	DPYSRPP	CBL_PTK	0.2778
p.R2456C	ACH-000972	Endometrial/Uterine Cancer	CCLE	DPYSRPP	CBL_PTK	0.2778
p.R2456C	ACH-000994	Endometrial/Uterine Cancer	CCLE	DPYSRPP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	CBL_PTK	2448:2454	DPYSRPP	CBL	0.9544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons