DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_2

Location: 1984:1990

E3 ligase: FBXW7

DEGRON score: 0.9463

ASA_SCORE: 96.8857

COIL: 0.9637

CONS_SCORE: 0.4871

DSS_SCORE: 0.8403

HELIX: 0.019

FCONS_SCORE: 0.9784

RIG_SCORE: 0.6176

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1997P	TCGA-A6-5666	COAD	TCGA	PTTPTTE	DEG_SCF_FBW7_2	0.1389
p.S1997P	DO9482	COAD	ICGC	PTTPTTE	DEG_SCF_FBW7_2	0.1389
p.T1974M	DO14678	HNSC	ICGC	PTTPTTE	DEG_SCF_FBW7_2	0.0556
p.P1984S	DO222843	MELA	ICGC	PTTPTTE	DEG_SCF_FBW7_2	0.6752
p.G1975S	DO232224	PBCA	ICGC	PTTPTTE	DEG_SCF_FBW7_2	0.0833
p.T1989A	ACH-000951	Lung Cancer	CCLE	PTTPTTE	DEG_SCF_FBW7_2	0.6028
p.T1989A	NCI-H2342	lung	COSMIC	PTTPTTE	DEG_SCF_FBW7_2	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_2	1984:1990	PTTPTTE	FBXW7	0.9463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons