DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: LIG_APCC_ABBA_1

Location: 1166:1171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 97.4833

COIL: 0.7033

CONS_SCORE: 0.4201

DSS_SCORE: 0.5796

HELIX: 0.2623

FCONS_SCORE: 0.9908

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1179D	TCGA-B5-A3FA	UCEC	TCGA	MEVYPE	LIG_APCC_ABBA_1	0.1111
p.G1179D	DO52402	UCEC	ICGC	MEVYPE	LIG_APCC_ABBA_1	0.1111
p.Q1178H	TCGA-LN-A9FP	ESCA	TCGA	MEVYPE	LIG_APCC_ABBA_1	0.1389
p.T1175I	DO234269	ESAD	ICGC	MEVYPE	LIG_APCC_ABBA_1	0.2222
p.P1170H	DO229045	LICA	ICGC	MEVYPE	LIG_APCC_ABBA_1	0.6583
p.Q1178K	DO229009	LICA	ICGC	MEVYPE	LIG_APCC_ABBA_1	0.1389
p.Y1169C	DO224734	PACA	ICGC	MEVYPE	LIG_APCC_ABBA_1	0.7087
p.T1164I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	MEVYPE	LIG_APCC_ABBA_1	0.7222
p.T1164I	ACH-000960	Leukemia	CCLE	MEVYPE	LIG_APCC_ABBA_1	0.7222
p.T1164I	REH	haematopoietic_and_lymphoid_tissue	COSMIC	MEVYPE	LIG_APCC_ABBA_1	0.7222
p.M1166V	SIDM00214	Colorectal Carcinoma	GDSC	MEVYPE	LIG_APCC_ABBA_1	0.6097
p.M1166V	ACH-000955	Colon/Colorectal Cancer	CCLE	MEVYPE	LIG_APCC_ABBA_1	0.6097
p.M1166V	SNU-407	large_intestine	COSMIC	MEVYPE	LIG_APCC_ABBA_1	0.6097
p.P1162H	ACH-000941	Endometrial/Uterine Cancer	CCLE	MEVYPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	LIG_APCC_ABBA_1	1166:1171	MEVYPE	APC,CDC20,FZR1	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons