DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1239:1247

E3 ligase: COP1

DEGRON score: 0.9272

ASA_SCORE: 99.5

COIL: 0.9682

CONS_SCORE: 0.2783

DSS_SCORE: 0.7287

HELIX: 0.0094

FCONS_SCORE: 0.9482

RIG_SCORE: 0.6409

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1232N	TCGA-BR-8680	STAD	TCGA	TPEPVVPTA	DEG_COP1_1	0.25
p.G1230E	TCGA-EO-A22U	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	0.0833
p.R1231I	TCGA-QS-A5YQ	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	0.1111
p.R1257Q	DO7938	COAD	ICGC	TPEPVVPTA	DEG_COP1_1	0.0556
p.S1244P	DO222590	COCA	ICGC	TPEPVVPTA	DEG_COP1_1	0.6752
p.R1249Q	DO51783	STAD	ICGC	TPEPVVPTA	DEG_COP1_1	0.2778
p.R1249Q	DO38232	STAD	ICGC	TPEPVVPTA	DEG_COP1_1	0.2778
p.D1239H	DO41518	UCEC	ICGC	TPEPVVPTA	DEG_COP1_1	0.7688
p.L1250F	ACH-001210	Rhabdoid	CCLE	TPEPVVPTA	DEG_COP1_1	0.25
p.N1233S	NCI-H1734	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	DBTRG-05MG	central_nervous_system	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	MDA-MB-157	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	CAL-85-1	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	KLE	endometrium	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	EMC-BAC-1	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	MHH-ES-1	bone	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	ESO26	oesophagus	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	SCaBER	urinary_tract	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	HPAF-II	pancreas	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	BT-483	breast	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	REH	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	U251	central_nervous_system	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	NCI-H23	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	H2810	pleura	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	A431	skin	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	NCI-H835	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	NCI-H1694	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667
p.N1233S	NCI-H1105	lung	COSMIC	TPEPVVPTA	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPEPVVPTA

Degron related mutations and impact score

Drug responses associated with MDC1 mutations

All proteins holding degron of TPEPVVPTA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1157:1165	TPEPVVPTA	COP1	0.9753	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1239:1247	TPEPVVPTA	COP1	0.9272	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1280:1288	TPEPVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1608:1616	TPEPVVPTA	COP1	0.9974	More...