DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1608:1616

E3 ligase: COP1

DEGRON score: 0.9974

ASA_SCORE: 101.2

COIL: 0.9723

CONS_SCORE: 0.3496

DSS_SCORE: 0.7366

HELIX: 0.009

FCONS_SCORE: 1.178

RIG_SCORE: 0.6041

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1605C	TCGA-BT-A3PH	BLCA	TCGA	TPEPVVPTA	DEG_COP1_1	0.6944
p.R1603W	TCGA-DD-AAE2	LIHC	TCGA	TPEPVVPTA	DEG_COP1_1	0.1944
p.V1606F	TCGA-KN-8424	KICH	TCGA	TPEPVVPTA	DEG_COP1_1	0.2778
p.P1617H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TPEPVVPTA	DEG_COP1_1	0.3056
p.T1615I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	TPEPVVPTA	DEG_COP1_1	0.7078
p.T1615I	ACH-001498	Lymphoma	CCLE	TPEPVVPTA	DEG_COP1_1	0.7078
p.T1615I	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	TPEPVVPTA	DEG_COP1_1	0.7078
p.E1618K	ACH-002019	Cervical Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1157:1165	TPEPVVPTA	COP1	0.9753	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1239:1247	TPEPVVPTA	COP1	0.9272	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1280:1288	TPEPVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1608:1616	TPEPVVPTA	COP1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons