DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1157:1165

E3 ligase: COP1

DEGRON score: 0.9753

ASA_SCORE: 98.5444

COIL: 0.9708

CONS_SCORE: 0.3247

DSS_SCORE: 0.738

HELIX: 0.0084

FCONS_SCORE: 0.8317

RIG_SCORE: 0.6367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1175Y	TCGA-CR-7388	HNSC	TCGA	TPEPVVPTA	DEG_COP1_1	0.0556
p.P1166H	TCGA-D1-A177	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	0.3056
p.P1162H	DO10132	COAD	ICGC	TPEPVVPTA	DEG_COP1_1	0.7694
p.T1169P	DO11567	GBM	ICGC	TPEPVVPTA	DEG_COP1_1	0.2222
p.S1166C	DO48884	LUAD	ICGC	TPEPVVPTA	DEG_COP1_1	0.3056
p.P1152L	DO27128	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	0.1944
p.T1161A	DO51284	SKCM	ICGC	TPEPVVPTA	DEG_COP1_1	0.7139
p.P1166S	SIDM01503	Small Cell Lung Carcinoma	GDSC	TPEPVVPTA	DEG_COP1_1	0.3056
p.P1166S	ACH-000844	Lung Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	0.3056
p.S1148N	SIDM01611	Endometrial Carcinoma	GDSC	TPEPVVPTA	DEG_COP1_1	0.0833
p.S1148N	ACH-000996	Endometrial/Uterine Cancer	CCLE	TPEPVVPTA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1157:1165	TPEPVVPTA	COP1	0.9753	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1239:1247	TPEPVVPTA	COP1	0.9272	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1280:1288	TPEPVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1608:1616	TPEPVVPTA	COP1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons