DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1280:1288

E3 ligase: COP1

DEGRON score: 0.9928

ASA_SCORE: 99.5667

COIL: 0.9683

CONS_SCORE: 0.3128

DSS_SCORE: 0.712

HELIX: 0.009

FCONS_SCORE: 0.982

RIG_SCORE: 0.6438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1286L	TCGA-AP-A1DV	UCEC	TCGA	TPEPVVPTA	DEG_COP1_1	0.7582
p.R1298K	DO459	BLCA	ICGC	TPEPVVPTA	DEG_COP1_1	0.0556
p.Q1281R	DO229505	LAML	ICGC	TPEPVVPTA	DEG_COP1_1	0.7329
p.S1276P	DO229505	LAML	ICGC	TPEPVVPTA	DEG_COP1_1	0.6667
p.R1292Q	DO230525	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	0.2222
p.S1289F	DO26518	LUSC	ICGC	TPEPVVPTA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1157:1165	TPEPVVPTA	COP1	0.9753	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1239:1247	TPEPVVPTA	COP1	0.9272	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1280:1288	TPEPVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1608:1616	TPEPVVPTA	COP1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons