DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: SCF_FBXL2

Location: 802:807

E3 ligase: FBXL2

DEGRON score: 0.9938

ASA_SCORE: 102.45

COIL: 0.9468

CONS_SCORE: 0.3462

DSS_SCORE: 0.708

HELIX: 0.0275

FCONS_SCORE: 1.0459

RIG_SCORE: 0.6171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E792D	TCGA-06-5416	GBM	TCGA	IQGRGR	SCF_FBXL2	0.0556
p.E792D	DO10880	GBM	ICGC	IQGRGR	SCF_FBXL2	0.0556
p.G806W	TCGA-64-5779	LUAD	TCGA	IQGRGR	SCF_FBXL2	0.7825
p.G806W	DO24930	LUAD	ICGC	IQGRGR	SCF_FBXL2	0.7825
p.G804V	TCGA-78-7153	LUAD	TCGA	IQGRGR	SCF_FBXL2	0.6421
p.G804V	DO26347	LUAD	ICGC	IQGRGR	SCF_FBXL2	0.6421
p.R807G	TCGA-BK-A0C9	UCEC	TCGA	IQGRGR	SCF_FBXL2	0.7568
p.R807G	DO41253	UCEC	ICGC	IQGRGR	SCF_FBXL2	0.7568
p.R805K	TCGA-VS-A9UP	CESC	TCGA	IQGRGR	SCF_FBXL2	0.7237
p.R805K	DO219737	CESC	ICGC	IQGRGR	SCF_FBXL2	0.7237
p.V814I	DO3910	BRCA	ICGC	IQGRGR	SCF_FBXL2	0.1389
p.P801L	DO50208	LGG	ICGC	IQGRGR	SCF_FBXL2	0.3056
p.Q803R	DO50836	LICA	ICGC	IQGRGR	SCF_FBXL2	0.7329
p.Q792E	DO25113	LUAD	ICGC	IQGRGR	SCF_FBXL2	0.0556
p.T813I	DO51272	SKCM	ICGC	IQGRGR	SCF_FBXL2	0.1667
p.R815C	DO48032	STAD	ICGC	IQGRGR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	SCF_FBXL2	802:807	IQGRGR	FBXL2	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons