DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_2

Location: 723:729

E3 ligase: FBXW7

DEGRON score: 0.9812

ASA_SCORE: 107.6286

COIL: 0.9093

CONS_SCORE: 0.3384

DSS_SCORE: 0.6208

HELIX: 0.0393

FCONS_SCORE: 0.8484

RIG_SCORE: 0.7045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S736I	TCGA-44-7662	LUAD	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.1389
p.S736I	DO23597	LUAD	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.1389
p.A721V	TCGA-FR-A8YC	SKCM	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.A721V	DO50301	SKCM	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.P727S	TCGA-FV-A2QR	LIHC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.5641
p.P727S	DO22837	LIHC	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.5641
p.P727L	DO50951	LICA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.6471
p.G731D	SIDM01109	Other Sarcomas	GDSC	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.G731D	ACH-000145	Sarcoma	CCLE	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.G731D	SK-LMS-1	soft_tissue	COSMIC	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.L730I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MLTPPQE	DEG_SCF_FBW7_2	0.3056
p.L730I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MLTPPQE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_2	723:729	MLTPPQE	FBXW7	0.9812	More...
Q99466	Neurogenic locus notch homolog protein 4	DEG_SCF_FBW7_2	1566:1572	MLTPPQE	FBXW7	0.7036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons