DegronMD

Uniprot ID: Q99466

Source protein: Neurogenic locus notch homolog protein 4

Source gene: NOTCH4

Class: DEG_SCF_FBW7_2

Location: 1566:1572

E3 ligase: FBXW7

DEGRON score: 0.7036

ASA_SCORE: 83.0857

COIL: 0.879

CONS_SCORE: 0.4481

DSS_SCORE: 0.6771

HELIX: 0.0673

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1564V	TCGA-AN-A0AK	BRCA	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.A1564V	DO1608	BRCA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.2778
p.T1582A	TCGA-AX-A2HJ	UCEC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.0556
p.T1582A	DO42105	UCEC	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.0556
p.A1560V	TCGA-OR-A5JP	ACC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	0.1667
p.E1572K	DO222494	MELA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_2	723:729	MLTPPQE	FBXW7	0.9812	More...
Q99466	Neurogenic locus notch homolog protein 4	DEG_SCF_FBW7_2	1566:1572	MLTPPQE	FBXW7	0.7036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons