DegronMD - Q99466(NOTCH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C1971F	TCGA-22-4593	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.5996
p.C1971F	DO27018	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.5996
p.E1977Q	TCGA-55-7995	LUAD	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.E1977Q	TCGA-DG-A2KK	CESC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.E1977Q	DO225215	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.E1977Q	DO227836	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.E1977Q	DO51595	CESC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.E1977Q	DO45323	LUAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6744
p.A1564V	TCGA-AN-A0AK	BRCA	TCGA	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation rewiring degron network	0.2778
p.A1564V	DO1608	BRCA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation rewiring degron network	0.2778
p.R1978L	TCGA-AP-A05A	UCEC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.3056
p.R1978L	DO218553	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.3056
p.R1978L	DO41530	UCEC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.3056
p.T1582A	TCGA-AX-A2HJ	UCEC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation rewiring degron network	0.0556
p.T1582A	DO42105	UCEC	ICGC	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation rewiring degron network	0.0556
p.P1970S	TCGA-EE-A29L	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6752
p.P1970S	DO222599	MELA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6752
p.P1970S	DO37835	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6752
p.P1966L	TCGA-EE-A29R	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.2222
p.P1966L	DO37448	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.2222
p.P1976S	TCGA-GN-A8LK	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.5641
p.P1976S	DO51259	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.5641
p.P1974R	TCGA-NK-A5CT	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7512
p.P1974R	DO219209	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7512
p.A1560V	TCGA-OR-A5JP	ACC	TCGA	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation rewiring degron network	0.1667
p.E1977K	TCGA-UY-A9PH	BLCA	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.E1977K	DO223594	BLCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.E1977K	SIDM00312	Plasma Cell Myeloma	GDSC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.E1977K	ACH-000183	Myeloma	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.E1977K	ACH-001395	Breast Cancer	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.E1977K	L-363	haematopoietic and lymphoid tissue	COSMIC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.7022
p.Q1982E	DO222490	BTCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.1944
p.S1975T	DO234398	ESAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation altering degron motif	0.6005
p.E1572K	DO222494	MELA	ICGC	MLTPPQE	DEG_SCF_FBW7_2	1566:1572	Mutation altering degron motif	0.7022
p.G1979V	DO46847	RECA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	1970:1977	Mutation rewiring degron network	0.2778

Kaplan plot for NOTCH4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOTCH4

UniProt ID: Q99466

Entrez ID: 4855

Protein name: Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOTCH4 in