DegronMD

Uniprot ID: Q99466

Source protein: Neurogenic locus notch homolog protein 4

Source gene: NOTCH4

Class: DEG_SCF_FBW7_2

Location: 1970:1977

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 76.7875

COIL: 0.8763

CONS_SCORE: 0.4951

DSS_SCORE: 0.5986

HELIX: 0.0679

FCONS_SCORE: 1.2044

RIG_SCORE: 0.6322

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1971F	TCGA-22-4593	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.5996
p.C1971F	DO27018	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.5996
p.E1977Q	TCGA-55-7995	LUAD	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	TCGA-DG-A2KK	CESC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO225215	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO227836	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO51595	CESC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO45323	LUAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.R1978L	TCGA-AP-A05A	UCEC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.3056
p.R1978L	DO218553	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.3056
p.R1978L	DO41530	UCEC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.3056
p.P1970S	TCGA-EE-A29L	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1970S	DO222599	MELA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1970S	DO37835	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1966L	TCGA-EE-A29R	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.2222
p.P1966L	DO37448	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.2222
p.P1976S	TCGA-GN-A8LK	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.5641
p.P1976S	DO51259	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.5641
p.P1974R	TCGA-NK-A5CT	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.7512
p.P1974R	DO219209	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.7512
p.E1977K	TCGA-UY-A9PH	BLCA	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	DO223594	BLCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	SIDM00312	Plasma Cell Myeloma	GDSC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	ACH-000183	Myeloma	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	ACH-001395	Breast Cancer	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.Q1982E	DO222490	BTCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.1944
p.S1975T	DO234398	ESAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6005
p.G1979V	DO46847	RECA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCLTPSPE

Degron related mutations and impact score

Drug responses associated with NOTCH4 mutations

All proteins holding degron of PCLTPSPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99466	Neurogenic locus notch homolog protein 4	DEG_SCF_FBW7_2	1970:1977	PCLTPSPE	FBXW7	0.999	More...