DegronMD

Uniprot ID: Q99466

Source protein: Neurogenic locus notch homolog protein 4

Source gene: NOTCH4

Class: DEG_SCF_FBW7_2

Location: 1970:1977

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 76.7875

COIL: 0.8763

CONS_SCORE: 0.4951

DSS_SCORE: 0.5986

HELIX: 0.0679

FCONS_SCORE: 1.2044

RIG_SCORE: 0.6322

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1974R	TCGA-NK-A5CT	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.7512
p.P1974R	DO219209	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.7512
p.E1977K	TCGA-UY-A9PH	BLCA	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	DO223594	BLCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	SIDM00312	Plasma Cell Myeloma	GDSC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	ACH-000183	Myeloma	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	ACH-001395	Breast Cancer	CCLE	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.E1977K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PCLTPSPE	DEG_SCF_FBW7_2	0.7022
p.P1970S	TCGA-EE-A29L	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1970S	DO222599	MELA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.P1970S	DO37835	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6752
p.E1977Q	TCGA-55-7995	LUAD	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	TCGA-DG-A2KK	CESC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO225215	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO227836	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO51595	CESC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.E1977Q	DO45323	LUAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6744
p.S1975T	DO234398	ESAD	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.6005
p.C1971F	TCGA-22-4593	LUSC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.5996
p.C1971F	DO27018	LUSC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.5996
p.P1976S	TCGA-GN-A8LK	SKCM	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.5641
p.P1976S	DO51259	SKCM	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.5641
p.R1978L	TCGA-AP-A05A	UCEC	TCGA	PCLTPSPE	DEG_SCF_FBW7_2	0.3056
p.R1978L	DO218553	BRCA	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.3056
p.R1978L	DO41530	UCEC	ICGC	PCLTPSPE	DEG_SCF_FBW7_2	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99466	Neurogenic locus notch homolog protein 4	DEG_SCF_FBW7_2	1970:1977	PCLTPSPE	FBXW7	0.999	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons