DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1485:1493

E3 ligase: COP1

DEGRON score: 0.9658

ASA_SCORE: 98.1333

COIL: 0.9613

CONS_SCORE: 0.2676

DSS_SCORE: 0.7114

HELIX: 0.0124

FCONS_SCORE: 0.9651

RIG_SCORE: 0.6912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1480K	TCGA-AP-A059	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	0.1944
p.R1480I	TCGA-DU-6392	LGG	TCGA	TPETVVPTA	DEG_COP1_1	0.1944
p.D1503H	TCGA-EY-A1GU	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	0.0556
p.S1479C	DO14348	HNSC	ICGC	TPETVVPTA	DEG_COP1_1	0.1667
p.P1494L	SIDM00712	Non-Cancerous	GDSC	TPETVVPTA	DEG_COP1_1	0.3056
p.P1494L	SIDM00713	Mesothelioma	GDSC	TPETVVPTA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1198:1206	TPETVVPTA	COP1	0.9906	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1321:1329	TPETVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1444:1452	TPETVVPTA	COP1	0.9875	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1485:1493	TPETVVPTA	COP1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons