DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1321:1329

E3 ligase: COP1

DEGRON score: 0.9928

ASA_SCORE: 96.1111

COIL: 0.967

CONS_SCORE: 0.3077

DSS_SCORE: 0.6581

HELIX: 0.0118

FCONS_SCORE: 1.0674

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1313K	TCGA-90-7766	LUSC	TCGA	TPETVVPTA	DEG_COP1_1	0.1111
p.T1321I	TCGA-AJ-A3EK	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	0.8189
p.S1318F	TCGA-AX-A06F	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	0.6944
p.T1328I	TCGA-HU-A4GN	STAD	TCGA	TPETVVPTA	DEG_COP1_1	0.8189
p.R1331W	DO6323	CESC	ICGC	TPETVVPTA	DEG_COP1_1	0.2778
p.C1335G	DO224664	COCA	ICGC	TPETVVPTA	DEG_COP1_1	0.1667
p.R1339W	DO52256	LIHC	ICGC	TPETVVPTA	DEG_COP1_1	0.0556
p.R1331Q	DO220885	MELA	ICGC	TPETVVPTA	DEG_COP1_1	0.2778
p.P1316S	DO222749	MELA	ICGC	TPETVVPTA	DEG_COP1_1	0.1944
p.P1326T	DO42673	UCEC	ICGC	TPETVVPTA	DEG_COP1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1198:1206	TPETVVPTA	COP1	0.9906	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1321:1329	TPETVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1444:1452	TPETVVPTA	COP1	0.9875	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1485:1493	TPETVVPTA	COP1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons