DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1444:1452

E3 ligase: COP1

DEGRON score: 0.9875

ASA_SCORE: 97.0444

COIL: 0.9594

CONS_SCORE: 0.3033

DSS_SCORE: 0.7379

HELIX: 0.0116

FCONS_SCORE: 1.0341

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1462E	TCGA-BW-A5NP	LIHC	TCGA	TPETVVPTA	DEG_COP1_1	0.0556
p.S1440F	TCGA-CV-A468	HNSC	TCGA	TPETVVPTA	DEG_COP1_1	0.6667
p.P1453L	TCGA-D3-A3MU	SKCM	TCGA	TPETVVPTA	DEG_COP1_1	0.3056
p.G1435D	TCGA-EO-A3AV	UCEC	TCGA	TPETVVPTA	DEG_COP1_1	0.0833
p.T1451A	TCGA-LP-A4AW	CESC	TCGA	TPETVVPTA	DEG_COP1_1	0.7139
p.E1435A	DO22237	LGG	ICGC	TPETVVPTA	DEG_COP1_1	0.0833
p.E1435Q	DO26593	LUSC	ICGC	TPETVVPTA	DEG_COP1_1	0.0833
p.P1439S	DO47368	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1198:1206	TPETVVPTA	COP1	0.9906	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1321:1329	TPETVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1444:1452	TPETVVPTA	COP1	0.9875	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1485:1493	TPETVVPTA	COP1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons