DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_COP1_1

Location: 1198:1206

E3 ligase: COP1

DEGRON score: 0.9906

ASA_SCORE: 95.7222

COIL: 0.9389

CONS_SCORE: 0.2496

DSS_SCORE: 0.6448

HELIX: 0.0231

FCONS_SCORE: 1.105

RIG_SCORE: 0.7202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1189V	TCGA-44-7662	LUAD	TCGA	TPETVVPTA	DEG_COP1_1	0.0833
p.S1194C	TCGA-44-7670	LUAD	TCGA	TPETVVPTA	DEG_COP1_1	0.2222
p.S1194C	DO506	BLCA	ICGC	TPETVVPTA	DEG_COP1_1	0.2222
p.E1208K	TCGA-DU-6407	LGG	TCGA	TPETVVPTA	DEG_COP1_1	0.2778
p.P1205H	DO639	BLCA	ICGC	TPETVVPTA	DEG_COP1_1	0.7694
p.P1205S	DO1608	BRCA	ICGC	TPETVVPTA	DEG_COP1_1	0.6752
p.R1216I	DO22237	LGG	ICGC	TPETVVPTA	DEG_COP1_1	0.0556
p.D1198E	DO52172	LIHC	ICGC	TPETVVPTA	DEG_COP1_1	0.6758
p.S1194Y	DO26526	LUSC	ICGC	TPETVVPTA	DEG_COP1_1	0.2222
p.T1195I	DO37406	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	0.25
p.P1189L	DO47337	SKCM	ICGC	TPETVVPTA	DEG_COP1_1	0.0833
p.R1216K	DO41361	UCEC	ICGC	TPETVVPTA	DEG_COP1_1	0.0556
p.T1205A	SIDM00449	B-Lymphoblastic Leukemia	GDSC	TPETVVPTA	DEG_COP1_1	0.7139
p.T1205A	SIDM00685	Glioblastoma	GDSC	TPETVVPTA	DEG_COP1_1	0.7139
p.T1205A	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	TPETVVPTA	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1198:1206	TPETVVPTA	COP1	0.9906	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1321:1329	TPETVVPTA	COP1	0.9928	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1444:1452	TPETVVPTA	COP1	0.9875	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_COP1_1	1485:1493	TPETVVPTA	COP1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons