DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1136:1142

E3 ligase: FBXW7

DEGRON score: 0.9837

ASA_SCORE: 102.4286

COIL: 0.9644

CONS_SCORE: 0.348

DSS_SCORE: 0.8058

HELIX: 0.0127

FCONS_SCORE: 1.0063

RIG_SCORE: 0.597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1143Y	TCGA-AX-A2HC	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.3056
p.P1139S	TCGA-EB-A3XC	SKCM	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.6752
p.P1127L	TCGA-W3-AA1V	SKCM	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.0833
p.R1126W	DO9514	COAD	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R1134I	DO233754	GACA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.G1137C	DO14766	HNSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.76
p.P1152L	DO27128	LUSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R1126Q	DO51784	STAD	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.A1134V	SIDM00126	Melanoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.A1134V	ACH-002147	Skin Cancer	CCLE	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.A1134V	K2	skin	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.S1148N	SIDM01611	Endometrial Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.1667
p.S1148N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTPKPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1136:1142	PVTPKPT	FBXW7	0.9837	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1300:1306	PVTPKPT	FBXW7	0.9946	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1341:1347	PVTPKPT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons