DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1341:1347

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 100.7714

COIL: 0.966

CONS_SCORE: 0.2454

DSS_SCORE: 0.7539

HELIX: 0.012

FCONS_SCORE: 1.164

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1344T	TCGA-A6-5665	COAD	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.7031
p.S1353N	TCGA-AX-A1CE	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.1667
p.T1347I	TCGA-B5-A1MX	UCEC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.8189
p.S1341C	DO856	BLCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.7541
p.R1331W	DO6323	CESC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.C1335G	DO224664	COCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.1667
p.V1342F	DO220468	KICH	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.5957
p.R1339W	DO52256	LIHC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.R1331Q	DO220885	MELA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.T1355K	SIDM01056	Breast Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.1111
p.T1355K	EFM-19	breast	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.1111
p.P1341T	SIDM01526	Mesothelioma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1136:1142	PVTPKPT	FBXW7	0.9837	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1300:1306	PVTPKPT	FBXW7	0.9946	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1341:1347	PVTPKPT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons