DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1300:1306

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 101.9286

COIL: 0.9607

CONS_SCORE: 0.3002

DSS_SCORE: 0.7852

HELIX: 0.0106

FCONS_SCORE: 1.019

RIG_SCORE: 0.6189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1313K	TCGA-90-7766	LUSC	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.1389
p.R1308W	TCGA-AN-A0AK	BRCA	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.R1308Q	TCGA-VQ-A8P2	STAD	TCGA	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.R1298K	DO459	BLCA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.2778
p.P1309A	DO22397	LGG	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.25
p.I1310V	DO231862	LINC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.2222
p.R1292Q	DO230525	LUSC	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.1111
p.P1316S	DO222749	MELA	ICGC	PVTPKPT	DEG_SCF_FBW7_1	0.0556
p.V1301L	SIDM00458	Acute Myeloid Leukemia	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	SIDM00820	Kidney Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	SIDM00842	Colorectal Carcinoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	COLO-320-HSR	large_intestine	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.5654
p.V1301L	RCC-ER	kidney	COSMIC	PVTPKPT	DEG_SCF_FBW7_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1136:1142	PVTPKPT	FBXW7	0.9837	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1300:1306	PVTPKPT	FBXW7	0.9946	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1341:1347	PVTPKPT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons