DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1423:1429

E3 ligase: FBXW7

DEGRON score: 0.9545

ASA_SCORE: 98.7286

COIL: 0.9619

CONS_SCORE: 0.329

DSS_SCORE: 0.8169

HELIX: 0.0127

FCONS_SCORE: 0.9266

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1433P	TCGA-06-1805	GBM	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.2222
p.S1430C	TCGA-55-8205	LUAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.75
p.E1415K	TCGA-AG-A002	READ	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.1111
p.G1435D	TCGA-EO-A3AV	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.P1426H	TCGA-G4-6628	COAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.7694
p.T1425A	TCGA-WE-A8ZM	SKCM	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.825
p.E1435A	DO22237	LGG	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.Q1413E	DO51195	LUAD	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.E1435Q	DO26593	LUSC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.P1439S	DO47368	SKCM	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.0556
p.S1422Y	DO41488	UCEC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.3056
p.P1426S	SIDM01768	Melanoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	0.6752
p.P1426S	ACH-000899	Skin Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1382:1388	PVTPEPT	FBXW7	0.991	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1423:1429	PVTPEPT	FBXW7	0.9545	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1464:1470	PVTPEPT	FBXW7	0.9908	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1546:1552	PVTPEPT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons