DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1546:1552

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 97.3429

COIL: 0.966

CONS_SCORE: 0.1377

DSS_SCORE: 0.8083

HELIX: 0.0134

FCONS_SCORE: 0.9943

RIG_SCORE: 0.6311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1553F	TCGA-85-6561	LUSC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.3056
p.R1562K	TCGA-DK-A1AD	BLCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.0556
p.G1558D	SIDM00151	Ovarian Carcinoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.G1558D	IGROV-1	ovary	COSMIC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.R1557K	ACH-001366	Neuroblastoma	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.1944
p.E1536K	ACH-002019	Cervical Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1382:1388	PVTPEPT	FBXW7	0.991	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1423:1429	PVTPEPT	FBXW7	0.9545	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1464:1470	PVTPEPT	FBXW7	0.9908	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1546:1552	PVTPEPT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons