DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1464:1470

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 96.5571

COIL: 0.9629

CONS_SCORE: 0.2944

DSS_SCORE: 0.8214

HELIX: 0.0124

FCONS_SCORE: 1.017

RIG_SCORE: 0.6236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1469S	TCGA-AN-A0AK	BRCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.5641
p.R1480K	TCGA-AP-A059	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.0556
p.D1462E	TCGA-BW-A5NP	LIHC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1480I	TCGA-DU-6392	LGG	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.0556
p.P1469H	TCGA-FD-A3N5	BLCA	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.6583
p.S1479C	DO14348	HNSC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.0833
p.T1470M	SIDM01965	Esophageal Carcinoma	GDSC	PVTPEPT	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1382:1388	PVTPEPT	FBXW7	0.991	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1423:1429	PVTPEPT	FBXW7	0.9545	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1464:1470	PVTPEPT	FBXW7	0.9908	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1546:1552	PVTPEPT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons