DegronMD

Uniprot ID: Q14676

Source protein: Mediator of DNA damage checkpoint protein 1

Source gene: MDC1

Class: DEG_SCF_FBW7_1

Location: 1382:1388

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 98.0429

COIL: 0.962

CONS_SCORE: 0.2827

DSS_SCORE: 0.8189

HELIX: 0.0124

FCONS_SCORE: 1.0008

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1389Y	TCGA-AX-A0J0	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.3056
p.S1389Y	TCGA-EO-A22R	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.3056
p.R1390W	TCGA-CM-5348	COAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.N1397H	TCGA-D1-A16Y	UCEC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.0833
p.R1395I	TCGA-F5-6814	READ	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.1389
p.N1397I	TCGA-F7-A61S	HNSC	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.0833
p.R1390Q	TCGA-VQ-A91E	STAD	TCGA	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1390Q	ACH-000897	Thyroid Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1390Q	ACH-000903	Thyroid Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1390Q	ACH-001390	Breast Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.R1390Q	FTC-133	thyroid	COSMIC	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.L1396F	DO2198	BRCA	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.2222
p.S1394F	DO49976	CESC	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.1667
p.S1382F	DO47268	SKCM	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.7982
p.R1380M	DO51761	STAD	ICGC	PVTPEPT	DEG_SCF_FBW7_1	0.2778
p.E1380K	ACH-002019	Cervical Cancer	CCLE	PVTPEPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1382:1388	PVTPEPT	FBXW7	0.991	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1423:1429	PVTPEPT	FBXW7	0.9545	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1464:1470	PVTPEPT	FBXW7	0.9908	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SCF_FBW7_1	1546:1552	PVTPEPT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons